Nikhil Kumar

Enzyme Catalytic Residues: a Study on Amino Acid Distribution in Enzyme Active Sites Nikhil Kumar

Enzyme's active site sequence is crucial to execute its functions. Enzymes of different origin have distinct preference of charged and polar amino acids at their active site. Certainly high probability occurrence of these amino acids does not indicate their conservation at the active site. The knowledge of amino acid frequency distribution at the active site can be exploited in designing novel enzyme's active site as well as their specific inhibitors.