Marina Vladimirovna Votintseva

Rasseyannyy Skleroz: Vzaimosvyaz' Kolichestva, Ob"ema Ochagov Demielinizatsii S Klinicheskoy Kartinoy I Aktivnost'yu Immunopatologicheskikh Protsessov Marina Vladimirovna Votintseva Russian edition

Ne vyzyvaet somneniya vedushchaya rol' immunopatologicheskikh reaktsiy v patogeneze rasseyannogo skleroza (RS). Osnovnym patomorfologicheskim substratom zabolevaniya yavlyayutsya ochagi demielinizatsii v tsentral'noy nervnoy sisteme (TsNS). Odnako morfologicheskim izmeneniyam pri RS podvergaetsya ne tol'ko mielinovaya obolochka nervnykh volokon, no i neposredstvenno aksony. Imenno aksonal'naya degeneratsiya yavlyaetsya prichinoy razvitiya stoykoy patologii v TsNS, privodyashchey k ranney invalidizatsii bol'nykh. Nalichie obshchikh strukturnykh i mediatornykh zven'ev nervnoy i immunnoy sistem obuslavlivaet sochetannye i vzaimozavisimye narusheniya funktsii TsNS i immunnoy sistem v patogeneze zabolevaniya. V svyazi s etim otsenka povrezhdeniya TsNS pri RS provoditsya parallel'no s primeneniem neyroradiologicheskikh i immunologicheskikh metodov. Analiz osobennostey vzaimosvyazi mezhdu klinicheskimi, immunologicheskimi i MRT-pokazatelyami, predstavlennymi v rabote, pozvolyaet sformirovat' novye podkhody v izuchenii mekhanizmov razvitiya zabolevaniya, rasshirit' vozmozhnosti ranney diagnostiki, ustanovit' stepen' aktivnosti patologicheskogo protsessa i optimizirovat' provodimuyu terapiyu.