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8-oksoguanin I Produkty Ego Okisleniya: Obrazovanie V Dnk in Vitro Pod Deystviem Tepla, Ionov Uranila I Gamma-izlucheniya Vadim Ivanovich Bruskov Russian edition
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8-oksoguanin I Produkty Ego Okisleniya: Obrazovanie V Dnk in Vitro Pod Deystviem Tepla, Ionov Uranila I Gamma-izlucheniya
Vadim Ivanovich Bruskov
Aktivnye formy kisloroda (AFK) obrazuyutsya v protsesse normal'nogo aerobnogo kletochnogo metabolizma i v rezul'tate vneshnikh vozdeystviy faktorov okruzhayushchey sredy na organizm. AFK chrezvychayno reaktsionnosposobny i mogut legko vstupat' v okislitel'no-vosstanovitel'nye reaktsii s lipidami, belkami, uglevodami i nukleinovymi kislotami. Eto vyzyvaet narusheniya metabolizma i strukturnoy organizatsii kletki. Naibolee chuvstvitel'noy mishen'yu pri deystvii AFK na DNK yavlyaetsya guanin, a produktom ego okislitel'nogo povrezhdeniya ? 8-oksoguanin (8-OG). 8-OG v nastoyashchee vremya schitaetsya odnim iz osnovnykh biomarkerov okislitel'nogo povrezhdeniya DNK. Ustanovlena svyaz' mezhdu obrazovaniem 8-OG i takimi protsessami kak mutagenez, kantserogenez, starenie i patogenezom bolezney pozhilogo vozrasta. Dannaya kniga posvyashchena issledovaniyu molekulyarnykh mekhanizmov, privodyashchikh k generatsii AFK, obrazovaniyu 8-oksoguanina i drugikh povrezhdeniy osnovaniy v DNK pod deystviem takikh faktorov sredy, kak teplo, gamma-izluchenie i iony uranila.
| Media | Books Paperback Book (Book with soft cover and glued back) |
| Released | October 18, 2011 |
| ISBN13 | 9783846526354 |
| Publishers | LAP LAMBERT Academic Publishing |
| Pages | 160 |
| Dimensions | 150 × 9 × 225 mm · 256 g |
| Language | German |