The Role of Cytokines on Synaptic Plasticity in the Dentate Gyrus - Derval Cumiskey - Books - LAP LAMBERT Academic Publishing - 9783844319941 - March 8, 2011
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Derval Cumiskey
The Role of Cytokines on Synaptic Plasticity in the Dentate Gyrus

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Pro-inflammatory cytokines have been implicated in a wide range of central nervous system (CNS) disorders, including trauma, ischemia, multiple sclerosis and Alzheimer?s disease. Tumour necrosis factor-? (TNF-?) and interleukin-18 (IL-18), both pro-inflammatory cytokines, have previously been shown to attenuate long-term potentiation (LTP), a proposed model for learning and memory. This study investigated the mechanisms underlying the TNF-? and IL-18 mediated inhibition of LTP. Initial experiments consolidate evidence on inducing LTP in the dentate gyrus of the hippocampus. Subsequent experiments consolidate evidence that TNF-? and IL-18 can impair LTP in the dentate gyrus.

Media Books     Paperback Book   (Book with soft cover and glued back)
Released March 8, 2011
ISBN13 9783844319941
Publishers LAP LAMBERT Academic Publishing
Pages 260
Dimensions 150 × 15 × 226 mm   ·   405 g
Language German  

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