Fizikova Anastasiya Yur'evna

Fosfat V Regulyatsii Funktsiy Mitokhondriy: Mekhanizmy Stabilizatsii Mitokhondrial'nogo Genoma U Drozhzhey Saccharomyces Cerevisiae I Pichia Pastoris Fizikova Anastasiya Yur'evna Russian edition

Izuchenie geneticheskikh mekhanizmov, obespechivayushchikh funktsionirovanie mitokhondriy i podderzhanie tselostnosti mtDNK, yavlyaetsya aktual'nym napravleniem sovremennykh issledovaniy, predstavlyayushchikh ne tol'ko fundamental'nyy interes, no i imeyushchikh nesomnennuyu prakticheskuyu tsennost'. U cheloveka vyyavleno mnozhestvo geneticheskikh zabolevaniy, svyazannykh s narusheniyami funktsiy mitokhondriy, mnogie iz kotorykh obuslovleny defektami mitokhondrial'nogo genoma. Klinicheskaya kartina zabolevaniy, razvitie kotorykh vyzvano disfunktsiey mitokhondriy, ves'ma raznoobrazna i mozhet privodit' kak k patologiyam serdtsa i pecheni, tak i k distrofii, mnozhestvu nervnykh zabolevaniy i psikhiatricheskikh rasstroystv, otkloneniyam v slukhe i k slepote. Drozhzhi predstavlyayut soboy unikal'nyy model'nyy ob"ekt dlya izucheniya mekhanizmov regulyatsii funktsiy mitokhondriy v zavisimosti ot metabolicheskogo sostoyaniya eukarioticheskoy kletki. V dannoy knige rassmotreny osnovnye mekhanizmy regulyatsii funktsiy mitokhondriy u drozhzhey s raznym tipom uglerodnogo i dykhatel'nogo metabolizmov Saccharomyces cerevisiae i Pichia pastoris.