Yadernye Retseptory Ppar V Regulyatsii Vospalitel'nykh Protsessov Mozga: Vzaimosvyaz' Izotipov Retseptorov Ppar Pri Aktivatsii Vrozhdennogo Immuniteta V Kletkakh Mozga - Marina Sergeeva - Books - LAP LAMBERT Academic Publishing - 9783843300957 - October 12, 2010
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Marina Sergeeva
Yadernye Retseptory Ppar V Regulyatsii Vospalitel'nykh Protsessov Mozga: Vzaimosvyaz' Izotipov Retseptorov Ppar Pri Aktivatsii Vrozhdennogo Immuniteta V Kletkakh Mozga Russian edition

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V monografii rassmotreny molekulyarnye mekhanizmy uchastiya yadernykh retseptorov PPAR (retseptory aktivatorov proliferatsii peroksisom) v regulyatsii vospalitel'nykh protsessov. PPAR reguliruyut transkriptsiyu bolee 1000 genov, uchastvuyushchikh v regulyatsii vrozhdennogo immuniteta, lipidnogo i uglevodnogo gomeostaza. Sinteticheskie ligandy PPAR - gipolipidemicheskie i gipoglikemicheskie lekarstva: roziglitazon, fenofibrat, bezafibrat i dr. Narushenie funktsiy PPAR nablyudaetsya pri ozhirenii, diabete 2 tipa, serdechno-sosudistykh i neyrodegenerativnykh zabolevaniyakh. Effektivnost' primeneniya ligandov PPAR dlya lecheniya insul'ta, travm mozga, bolezney Al'tsgeymera i Parkinsona pokazana na zhivotnykh. Avtorami provedeno eksperimental'noe issledovanie vzaimosvyazi tryekh izotipov retseptorov PPAR?, -?, -? pri aktivatsii kletok glii. Opisan mekhanizm vzaimodeystviya izotipov v regulyatsii tsiklooksigenazy 2 i fosfolipaz A2, fermentov sinteza prostaglandinov i vyshchepleniya iz fosfolipidov ?-6/ ?-3 zhirnykh kislot. Eti veshchestva yavlyayutsya endogennymi ligandami PPAR i mediatorami vospaleniya. Obsuzhdaetsya vozmozhnost' ispol'zovaniya dvoynykh agonistov i ingibitorov sinteza prostaglandinov dlya regulyatsii dinamiki vospalitel'nogo protsessa.

Media Books     Paperback Book   (Book with soft cover and glued back)
Released October 12, 2010
ISBN13 9783843300957
Publishers LAP LAMBERT Academic Publishing
Pages 156
Dimensions 150 × 9 × 225 mm   ·   250 g
Language German  

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