Mechanisms of Altered Hepatotoxicity in Nonalcoholic Fatty Liver: Mechanisms of Altered Hepatotoxicity in Hepatic Steatosis and Nonalcoholic Steatohepatitis - Shashikiran Donthamsetty - Books - LAP Lambert Academic Publishing - 9783838309712 - September 15, 2009
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Shashikiran Donthamsetty
Mechanisms of Altered Hepatotoxicity in Nonalcoholic Fatty Liver: Mechanisms of Altered Hepatotoxicity in Hepatic Steatosis and Nonalcoholic Steatohepatitis

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The objectives of this research were to investigate 1) if hepatic steatosis and nonalcoholic steatohepatitis (NASH) independently sensitize the liver to hepatotoxicity and 2) the mechanisms behind the increased sensitivity. Our study suggests that fatty hepatocytes fail to undergo compensatory cell division rendering the liver susceptible to progressive expansion of liver injury. In conclusion, impaired tissue repair response sensitizes the steatotic/steatohepatitic livers to hepatotoxicity.

Media Books     Paperback Book   (Book with soft cover and glued back)
Released September 15, 2009
ISBN13 9783838309712
Publishers LAP Lambert Academic Publishing
Pages 136
Dimensions 225 × 8 × 150 mm   ·   221 g
Language German  

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