R-ras Proteins, Tgf-beta and Cancer: Mechanisms of Interaction Among the R-ras, Tc21 and Tgf-beta Signaling Pathways - Mete Erdogan - Books - LAP Lambert Academic Publishing - 9783838306643 - August 6, 2009
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Mete Erdogan
R-ras Proteins, Tgf-beta and Cancer: Mechanisms of Interaction Among the R-ras, Tc21 and Tgf-beta Signaling Pathways

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During the progression of human cancers, normal cells acquire genetic and epigenetic changes in the signaling pathways that govern their proliferation, resulting in uncontrolled growth and tumor formation. Oncogenic Ras and Transforming Growth Factor-Beta are known to cooperate in promoting malignant transformation, yet the mechanism by which they interact has not been established. Here, we present novel mechanisms through which Transforming Growth Factor-Beta interacts with two Ras-related proteins, R-Ras and TC21, to transform mammary epithelial cells.

Media Books     Paperback Book   (Book with soft cover and glued back)
Released August 6, 2009
ISBN13 9783838306643
Publishers LAP Lambert Academic Publishing
Pages 112
Dimensions 225 × 7 × 150 mm   ·   185 g
Language German  

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