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Sozdanie Liposomal'nykh Lekarstvennykh Form Protivoopukholevykh Preparatov: Liposomal'nye Preparaty Proizvodnykh Bis-(-khloretil)amina Nataliya Aleksandrovna Oborotova Russian edition
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Sozdanie Liposomal'nykh Lekarstvennykh Form Protivoopukholevykh Preparatov: Liposomal'nye Preparaty Proizvodnykh Bis-(-khloretil)amina
Nataliya Aleksandrovna Oborotova
Diagnoz «rak» stal prigovorom dlya mnogikh lyudey. V mire ezhegodno fiksiruetsya 12 millionov novykh sluchaev onkologicheskikh zabolevaniy. V 40-kh gg. KhKh v. otechestvennyy uchenyy L. F. Larionov predlozhil ispol'zovat' aminokisloty, obespechivayushchie selektivnost' deystviya preparatov na DNK rakovykh kletok, v kachestve «nositeley» tsitotoksicheskoy khimicheskoy gruppy bis-(?-khloretil)-amina. V sootvetstvii s etoy ideey v FGBU «RONTs im. N. N. Blokhina» RAMN sintezirovany pervye otechestvennye preparaty: sarkolizin i ego peptidnoe proizvodnoe ? tsifelin. No terapevticheskiy effekt sarkolizina sopryazhen s ryadom pobochnykh deystviy, a menee toksichnyy tsifelin v silu nerastvorimosti v vode obladaet nizkoy biodostupnost'yu. Sokhranenie i prodlenie zhizni mnogikh onkologicheskikh bol'nykh pryamo zavisit ot primeneniya innovatsionnykh lekarstvennykh form. Odno iz interesnykh i bystro razvivayushchikhsya napravleniy sovremennykh issledovaniy v oblasti farmatsii ? primenenie liposom v kachestve nositeley dlya dostavki lekarstvennykh veshchestv k patologicheski izmenennym kletkam. V svyazi s etim aktual'noy yavlyaetsya razrabotka novykh LF izvestnykh protivoopukholevykh veshchestv ? stericheski stabilizirovannykh liposom proizvodnykh bis-(?-khloretil)amina.
| Media | Books Paperback Book (Book with soft cover and glued back) |
| Released | May 8, 2014 |
| ISBN13 | 9783659283888 |
| Publishers | LAP LAMBERT Academic Publishing |
| Pages | 180 |
| Dimensions | 150 × 10 × 225 mm · 286 g |
| Language | German |