Gen Mthfr: Populyatsionnaya Genetika I Rol' Pri Koronarnom Ateroskleroze: Struktura Neravnovesiya Po Stsepleniyu Gena Mthfr V Populyatsiyakh Severnoy ... Koronarnym Aterosklerozom - Vadim Stepanov - Books - LAP LAMBERT Academic Publishing - 9783659106057 - June 18, 2012
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Vadim Stepanov
Gen Mthfr: Populyatsionnaya Genetika I Rol' Pri Koronarnom Ateroskleroze: Struktura Neravnovesiya Po Stsepleniyu Gena Mthfr V Populyatsiyakh Severnoy ... Koronarnym Aterosklerozom Russian edition

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Arkhitektura neravnovesiya po stsepleniyu (LD) v genome cheloveka yavlyaetsya predmetom ozhivlennykh issledovaniy pri izuchenii demograficheskoy istorii populyatsiy i kartirovanii genov MFZ. Osnovoy raboty stalo vyyavlenie struktury gaplotipov i neravnovesiya po stsepleniyu v gene MTHFR u naseleniya Severnoy Evrazii i vyyavleniya osobennostey stroeniya dlya bol'nykh koronarnym aterosklerozom (KA). V rabote identifitsirovany informativnye markery (tagSNPs), opisyvayushchie strukturu gaplotipov v gene MTHFR; pokazan kharakter neravnovesiya po stsepleniyu v gene MTHFR u bol'nykh KA i provedyen analiz assotsiatsiy issledovannykh SNPs gena MTHFR s patogeneticheski znachimymi kolichestvennymi priznakami. Vpervye pokazano, chto struktura LD v gene MTHFR nosit populyatsionno-spetsifichnyy kharakter. Proizvedena otsenka vozrasta generatsii raznoobraziya po 12 SNP gena MTHFR. Vyyavlena rol' gaplotipov pri formirovanii KA v russkoy populyatsii. Naydeny assotsiatsii polimorfizmov rs7533315 i rs2066462 s KA. Polucheny dannye o vzaimosvyazi geneticheskoy variabel'nosti lokusa MTHFR u bol'nykh KA s patogeneticheski znachimymi pokazatelyami lipidnogo obmena, prodemonstrirovana vysokaya informativnost' gaplotipicheskogo podkhoda.

Media Books     Paperback Book   (Book with soft cover and glued back)
Released June 18, 2012
ISBN13 9783659106057
Publishers LAP LAMBERT Academic Publishing
Pages 160
Dimensions 150 × 9 × 225 mm   ·   244 g
Language Russian  

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