Optimal Design for Nonlinear Response Models - Valerii V. Fedorov - Books - Taylor & Francis Ltd - 9780367379803 - September 19, 2019
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Valerii V. Fedorov
Optimal Design for Nonlinear Response Models 1st edition

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Optimal Design for Nonlinear Response Models discusses the theory and applications of model-based experimental design with a strong emphasis on biopharmaceutical studies. The book draws on the authors? many years of experience in academia and the pharmaceutical industry.





While the focus is on nonlinear models, the book begins with an explanation of the key ideas, using linear models as examples. Applying the linearization in the parameter space, it then covers nonlinear models and locally optimal designs as well as minimax, optimal on average, and Bayesian designs. The authors also discuss adaptive designs, focusing on procedures with non-informative stopping.





The common goals of experimental design?such as reducing costs, supporting efficient decision making, and gaining maximum information under various constraints?are often the same across diverse applied areas. Ethical and regulatory aspects play a much more prominent role in biological, medical, and pharmaceutical research. The authors address all of these issues through many examples in the book.

402 pages

Media Books     Paperback Book   (Book with soft cover and glued back)
Released September 19, 2019
ISBN13 9780367379803
Publishers Taylor & Francis Ltd
Pages 402
Dimensions 150 × 220 × 10 mm   ·   453 g
Language English  

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